| Sassafras Gap | 1344 m | | Cheoah Mountains |
| Chambers Creek Gap | 1337 m | | Central Great Smoky Mountains |
| Deep Gap | 1323 m | | Nantahala Mountains |
| Soco Gap | 1323 m | | Balsam |
| Mud Gap | 1317 m | | Western Great Smoky Mountains |
| Mccampbell Gap | 1316 m | | Western Great Smoky Mountains |
| Betty Creek Gap | 1311 m | | Georgia Blue Ridge |
| Brier Lick Gap | 1306 m | | Western Great Smoky Mountains |
| Panther Spring Gap | 1301 m | | Balsam |
| Upper Sassafras Gap | 1294 m | | Central Great Smoky Mountains |
| Burningtown Gap | 1291 m | | Nantahala Mountains |
| Coleman Gap | 1286 m | | Georgia Blue Ridge |
| Cowee Gap | 1280 m | | South North Carolina Blue Ridge Crest |
| Haw Gap | 1273 m | | North North Carolina Blue Ridge Crest |
| Low Gap | 1272 m | | Eastern Great Smoky Mountains |
| Catpen Gap | 1259 m | | Newfound Mountain Region |
| Licklog Gap | 1257 m | | Central Great Smoky Mountains |
| Swinging Lick Gap | 1250 m | | Nantahala Mountains |
| Little Abrams Gap | 1250 m | | Western Great Smoky Mountains |
| Long Branch Gap | 1248 m | | Eastern Great Smoky Mountains |